Chitrakmool Plumbago Zeylanica safety, side effects, toxicity

In Ayurvedic medicine, chitrakmool has been mentioned as having pungent, astringent, diuretic, germicidal, and vesicant properties. Others mention chitrakmool to have benefit in terms of digestive, nervous and female reproductive system. Used in indigestion, gas, hemorrhoids, rheumatism, promotes sweating and small doses stimulate the central nervous system. See a list of Ayurvedic herbs. Chitrakmool is also a medicinal plant commonly used in Ethiopia for skin diseases.

As of April 2009 we could not find published human research with Chitrakmool herb.

Chitrakmool and prostate cancer
Human prostate cancer cell growth is inhibited by plumbagin, a constituent of the widely used medicinal herb chitrakmool.

Substances in chtrakmool
Aerial parts of chtrakmool have plumbagin, isoshinanolone, plumbagic acid, beta-sitosterol, 4-hydroxybenzaldehyde, trans-cinnamic acid, vanillic acid, 2, 5-dimethyl-7-hydroxychromone, and indole-3-carboxaldehyde.

Chitrakmool safety, side effects, toxicity
G
enotoxicity of plumbagin and its effects on catechol and NQNO-induced DNA damage in mouse lymphoma cells.
Toxicol In Vitro. 2009 Mar; Demma J, Hallberg K, Hellman B. Department of Pharmaceutical Biosciences, Uppsala University, Division of Toxicology, Box 594, BMC, SE-751 24 Uppsala, Sweden.
Plumbagin, a naphtoquinone present in the roots of
plumbago zeylanica has been reported to have many beneficial effects such as antibacterial, antifungal, anticancer, antimutagenic and antioxidant effects, but this compound has also been reported to have many side effects. Given the wide use of P. zeylanica in traditional medicine and the various potential therapeutic uses of plumbagin, the present study was carried out to further elucidate the potential genotoxicity and antigenotoxicity of plumbagin in mouse lymphoma L5178Y cells, using the comet assay. Without affecting the cell viability, plumbagin itself was found to induce significant DNA damage at concentrations as low as 0.25ng/ml. When the cells were exposed to non-DNA damaging concentrations of plumbagin, together with NQNO (known to interact with DNA in many different ways) or catechol (known to induce oxidative DNA damage), plumbagin was found to significantly reduce the catechol-induced DNA damage, but to be without protective effect against the NQNO-induced damage. The fact that non-DNA damaging concentrations of plumbagin diminished the DNA damage induced by catechol, provides further support for the idea that plumbagin may act as an antioxidative agent at low concentrations.

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