Casuarinin tannin health benefit and potential use as anti-cancer agent
Casuarinin is a hydrolyzable tannin isolated from the bark of Terminalia arjuna plant. Casuarinin is an antioxidant. A number of laboratory studies show potential benefits from this compound but human trials are required before jumping to conclusions. For more arjuna bark research information.
As of 2010, we could not find human studies with casuarinin supplements.
Casuarinin and breast cancer benefit
Casuarinin was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. The results showed that casuarinin inhibited the proliferation of MCF-7 by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis.
Casuarinin and lung cancer benefit
Casuarinin inhibits human non-small cell lung cancer A549 cells by blocking cell cycle progression in the G0/G1 phase and inducing apoptosis.
Casuarinin possesses anti-herpes virus activity in inhibiting viral attachment and penetration.
Casuarinin is found in:
Eucalyptus nitens sapwood has the ellagitannins pedunculagin, tellimagrandin I, casuarinin, casuarictin and tellimagrandin II.
Eugenia jambos is an antipyretic and anti-inflammatory herb of Asian folk medicine. A 70% acetone extract exerted strong cytotoxic effects on human leukemia cells (HL-60). The cytotoxic principles were due to two hydrolyzable tannins, 1-O-galloyl castalagin and casuarinin.
Melastoma dodecandrum has casuarinin, casuarictin, pedunclagin and nobotannin B.
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